Biopsy:to detect diseases of human body

Biopsy is one kind of medical examination,that is done surgeon or interventional radiologists which is done a part of tissue from body.Either disease have or not by testing tissue by biopsy;if have,how much severity of the disease.

Pathologists examine this tissue under microscope.Bio means life and opsia means source of origin.Arabian physicians Abul Kashem discovered this method to diagnosis diseases.In 1879,skin specialist Arnest Besnear of France,has applied 6this biopsy in health science.

Excisional biopsy-when total part or nodule or doubt are is taken,is called excisional biopsy.

Incisional biopsy-when it is taken a little part from affected area,is called incisional biopsy or core biopsy.

Needle aspiration biopsy-When taken a little part or liquid by a needle,is called needle aspiration  biopsy or FNAC.Generally it is done by CT scan or ultrasound.

Bone marrow biopsy-blood cells is making from bone marrow.Bone marrow biopsy is indicated when disease is not found out of testing blood.To diagnosis stage of blood cancer,it is indicated such as leukemia,lymphoma

Esophagus-it is done of colon to indicate esophagus by endoscopy and colonoscopy..

3.Needle biopsy can be used by CT scan and USG guided and bronchoscopy,lung needle and pleural biopsy should indicate according to condition.



Liver-it is examined to enter a needle into a liver to collect liver tissue.

Prostate-this biopsy is indicated of anal and urinal path.

Nervous system-it is indicated of brain,nerve,urinary bladder,kidney and cervix

Other-breast,lymph-gland,muscles,skin biopsy

-Colposcopy directed biopsy
-Frozen section biopsy-Pathologists provide report biopsy during operation and according to this report ,surgeon has completed another operation at once.Bone biopsy is indicated also in orthopedic operation.

Risk of biopsy:
1,Blood excreting after biopsy
2.Contagious of germs
3.Pain-but medicines are given at the time of biopsy

Histopathology,it is a Greek word.Histos means tissue and patho means disease-suffering and log means knowledge hence tissue should be tested by microscope to know disease condition.Pathologists diagnosis the disease by slide preparation by biopsy.On the other hand,cytopathology is indicated examination of tissue.

Why biopsy: 
Most cases to find out cancer cells,it is applied.Besides this,other situation can be applied it such as contagious of germs,and infection,and auto-immune problem such as lupus.If lump or mass found in breast by mammogram or ultrasonogram,then for over confirmed biopsy is needed.

Melanoma which is skin cancer,can be assured by biopsy.If anyone is suffering chronic hepatitis,to confirm cirrhosis or liver cancer,biopsy is needed.It is possible to give proper treatment by biopsy.

What type of disease to find out:
1.Cancer-Biopsy is assured in various way if any one is affected by cancer or cancer doubt.If pathologists find clear margin or negative margin,then doctor understand that it does spread adjacent area.Positive margin means cancer is spreading adjacent area-for this reason,surgery should be taken to dissect adjacent area.But it depends on diagnosis.Pathologists confirm that eiter cancer or not.Even discriminate cancer such as sub classification  cancer and histologic grading.

2.Precancerous condition-can be diagnosis doubtful condition -what was in skin or outside.Later x-ray,CT scan,MRI,ultrasonogram,endoscopy,is indicated spreading other area or increasing.

3.Infected condition-caseation can be found by biopsy of lymph-node,if doctor doubt tuberculosis.

Temporal arteritis can be done by biopsy if doctor doubt vasculitis.Primary cancer may be diagnosis by repeated biopsy in case of IBD that means crohn,s disease and ulcerative colitis.

Changing protein is depositing in various tissue in body in case of amyloidosis.

Biopsy at transplantation organ -we can make sure that organ is not denied or re-gain after transplantation.

Testicular biopsy we can find out men,s reproduction power and also find out cause of inability  to production of child while hormone is normal and at the same time low amount of testis quality.


It is easily find out crescentic glomerulonephritis by immunofluorescence.